Adapalene
6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid
Third-generation synthetic retinoid; teratogenic - contraindicated in pregnancy; OTC only in the US at 0.1%; prescription-only in India, EU, Korea, Canada, Australia; causes photosensitivity.
Function & Common Use
Retinoid / Keratolytic / Anti-acne (Drug only)
Vitamins
Prescription/OTC acne gels and creams (Differin 0.1% gel)
Synthetic
Concentration Limits
Not permitted in cosmetics; Schedule H prescription drug
Not permitted as cosmetic ingredient in EU
0.1% OTC (Differin); higher concentrations Rx only
Not permitted in cosmetics; Rx prescription only
Format restriction: Pharmaceutical drug only; OTC at 0.1% in US only; prescription everywhere else; NOT a cosmetic ingredient
Baby restriction: Yes
Pregnancy: Yes
IFRA: No
Frequently Asked Questions
Is Adapalene safe to use in skincare?
Adapalene has a High concern rating. Third-generation synthetic retinoid; teratogenic - contraindicated in pregnancy; OTC only in the US at 0.1%; prescription-only in India, EU, Korea, Canada, Australia; causes photosensitivity.
Is Adapalene allowed in India?
Adapalene is currently classified as "Restricted - Prescription Only Drug (Schedule H)" under Indian cosmetics regulations. The maximum permitted concentration is Not permitted in cosmetics; Schedule H prescription drug.
What is Adapalene used for in cosmetics?
Adapalene functions as: Retinoid / Keratolytic / Anti-acne (Drug only). It is commonly found in: Prescription/OTC acne gels and creams (Differin 0.1% gel).
Can Adapalene cause an allergic reaction?
Yes. Adapalene has an allergen flag (No). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.
Is Adapalene safe for babies?
Adapalene has baby/child restrictions: Yes. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.
Regulatory Status
EU Annex: None
Identifiers
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