Ingredient Directory
Low ConcernVegan

Azadirachta Indica Seed Oil

Neem seed oil; cold-pressed or refined oil from seeds of Azadirachta indica (neem tree)

Safety Flags
Allergen: None identified for refined seed oil; unrefined/crude neem oil has strong odour; contact dermatitis reported rarely with crude oil
Safety Notes

Rich in oleic acid (~50%) and palmitic acid; contains tetranortriterpenes (azadirachtin, nimbin, nimbidin) at trace levels in refined oil; strong sulfurous odour in crude form - deodorised/refined grades preferred in cosmetics; antimicrobial and anti-inflammatory; traditional Indian cosmetic ingredient (5000-year history); comedogenicity moderate (2-3/5); distinguish from neem leaf extract (different INCI, different regulatory profile)

Function & Common Use

Function

Emollient / Skin conditioning / Antimicrobial / Insect repellent

Category

Plant Oil / Emollient

Common In

Anti-dandruff hair care, scalp treatments, acne-targeting products, body oils, Ayurvedic cosmetics

Origin

Plant derived

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit for cosmetic use; note EU Biocidal Products Regulation (BPR) 528/2012 regulates neem-based insect repellents separately

US FDA (21 CFR)

No limit for cosmetic use; note EPA pesticide registration is separate

Korea (MFDS)

No limit

Baby restriction: Use refined oil; strong odour of crude oil may limit use; no formal restriction identified

Pregnancy: Oral neem preparations have historical emmenagogue use - not applicable to refined topical cosmetic seed oil; no restriction identified for cosmetic use

Frequently Asked Questions

Is Azadirachta Indica Seed Oil safe to use in skincare?

Azadirachta Indica Seed Oil has a Low concern rating from The Clean Sheet. Rich in oleic acid (~50%) and palmitic acid; contains tetranortriterpenes (azadirachtin, nimbin, nimbidin) at trace levels in refined oil; strong sulfurous odour in crude form - deodorised/refined grades preferred in cosmetics; antimicrobial and anti-inflammatory; traditional Indian cosmetic ingredient (5000-year history); comedogenicity moderate (2-3/5); distinguish from neem leaf extract (different INCI, different regulatory profile)

Is Azadirachta Indica Seed Oil allowed in India?

Azadirachta Indica Seed Oil is currently classified as "Permitted cosmetic ingredient under Cosmetics Rules 2020; traditional Ayurvedic ingredient with long established use in India" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Azadirachta Indica Seed Oil used for in cosmetics?

Azadirachta Indica Seed Oil functions as: Emollient / Skin conditioning / Antimicrobial / Insect repellent. It is commonly found in: Anti-dandruff hair care, scalp treatments, acne-targeting products, body oils, Ayurvedic cosmetics.

Can Azadirachta Indica Seed Oil cause an allergic reaction?

Yes. Azadirachta Indica Seed Oil has an allergen flag (None identified for refined seed oil; unrefined/crude neem oil has strong odour; contact dermatitis reported rarely with crude oil). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

Is Azadirachta Indica Seed Oil safe for babies?

Azadirachta Indica Seed Oil has baby/child restrictions: Use refined oil; strong odour of crude oil may limit use; no formal restriction identified. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted cosmetic ingredient under Cosmetics Rules 2020; traditional Ayurvedic ingredient with long established use in India
EU
Permitted (listed in EU CosIng inventory; no Annex restriction; note ECHA has registered some neem-derived biocidal actives separately from cosmetic seed oil)
US FDA
Permitted cosmetic ingredient; no 21 CFR restriction for cosmetic use; neem oil has EPA registration as pesticide (separate from cosmetic use)
Korea (MFDS)
Permitted cosmetic ingredient; check MFDS positive list if used in functional cosmetic categories
Australia (TGA)
Permitted cosmetic ingredient; APVMA regulates neem as pesticide separately; cosmetic seed oil use permitted under TGA cosmetic framework
Canada (NHPID)
Permitted cosmetic ingredient; no restriction identified under Health Canada cosmetic notification framework

EU Annex: None

Identifiers

CAS8002-65-1
EC232-449-5

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