Ingredient Directory
Medium ConcernVegan Evaluator Flag

CI 45380

Eosin Y (D&C Red No. 22; disodium 2',4',5',7'-tetrabromofluorescein)

Safety Flags
Allergen: Yes
Safety Notes

Eosin Y is a photosensitizer - can cause photosensitivity reactions upon sun exposure. Classic lipstick staining agent. Not permitted for eye area. Rare allergic contact sensitization reported.

Function & Common Use

Function

Colorant

Category

Colorants & Pigments

Common In

Lipsticks (classic lip stain ingredient), blushes, nail polish

Origin

Synthetic

Concentration Limits

India (CDSCO)

As per Schedule III

EU Cosmetics Reg.

As per Annex IV; not for eye area; lips and face only

US FDA (21 CFR)

qs (requires batch certification); restricted to external use - not eye area

Korea (MFDS)

None specified

Format restriction: Not for eye area use; primarily lips and face; EU Annex IV restricts to non-eye area

Baby restriction: No

Pregnancy: No

IFRA: No

Frequently Asked Questions

Is CI 45380 safe to use in skincare?

CI 45380 has a Medium concern rating. Eosin Y is a photosensitizer - can cause photosensitivity reactions upon sun exposure. Classic lipstick staining agent. Not permitted for eye area. Rare allergic contact sensitization reported.

Is CI 45380 allowed in India?

CI 45380 is currently classified as "Permitted" under Indian cosmetics regulations. The maximum permitted concentration is As per Schedule III.

What is CI 45380 used for in cosmetics?

CI 45380 functions as: Colorant. It is commonly found in: Lipsticks (classic lip stain ingredient), blushes, nail polish.

Can CI 45380 cause an allergic reaction?

Yes. CI 45380 has an allergen flag (Yes). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

Is CI 45380 safe for babies?

CI 45380 has baby/child restrictions: No. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment
Medium Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Certifiable
Korea (MFDS)
Permitted
Australia (TGA)
Permitted
Canada (NHPID)
Permitted

EU Annex: Annex IV (colorant)

Identifiers

CAS17372-87-1
EC241-409-6

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