Ingredient Directory
Medium ConcernVegan Evaluator Flag

CI 45410

Phloxine B (D&C Red No. 28; disodium 2',4',5',7'-tetrabromo-4,5,6,7-tetrachlorofluorescein)

Safety Flags
Allergen: Yes
Safety Notes

Xanthene dye closely related to Eosin; photosensitizer with potential for phototoxic and allergic reactions. Not for eye area. Batch certification required in US.

Function & Common Use

Function

Colorant

Category

Colorants & Pigments

Common In

Lipsticks, blushes, lip glosses

Origin

Synthetic

Concentration Limits

India (CDSCO)

As per Schedule III

EU Cosmetics Reg.

As per Annex IV; not for eye area

US FDA (21 CFR)

qs (requires batch certification); not for eye area

Korea (MFDS)

None specified

Format restriction: Not for eye area use; EU Annex IV and US FDA restrict from eye area

Baby restriction: No

Pregnancy: No

IFRA: No

Frequently Asked Questions

Is CI 45410 safe to use in skincare?

CI 45410 has a Medium concern rating. Xanthene dye closely related to Eosin; photosensitizer with potential for phototoxic and allergic reactions. Not for eye area. Batch certification required in US.

Is CI 45410 allowed in India?

CI 45410 is currently classified as "Permitted" under Indian cosmetics regulations. The maximum permitted concentration is As per Schedule III.

What is CI 45410 used for in cosmetics?

CI 45410 functions as: Colorant. It is commonly found in: Lipsticks, blushes, lip glosses.

Can CI 45410 cause an allergic reaction?

Yes. CI 45410 has an allergen flag (Yes). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

Is CI 45410 safe for babies?

CI 45410 has baby/child restrictions: No. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment
Medium Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Certifiable
Korea (MFDS)
Permitted
Australia (TGA)
Permitted
Canada (NHPID)
Permitted

EU Annex: Annex IV (colorant)

Identifiers

CAS18472-87-2
EC242-355-6

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