The Clean Sheet
Ingredient Directory
Low ConcernVegan

Dimethyl Isosorbide

1,4:3,6-Dianhydro-2,5-di-O-methylsorbitol

Safety Notes

Penetration enhancer for actives; plant-origin feedstock; low irritancy

Function & Common Use

Function

Solvent / Penetration enhancer

Category

Solvent / Carrier

Common In

Serums, actives delivery systems

Origin

Synthetic (plant-derived starch origin)

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked; EU limit reference: None

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Dimethyl Isosorbide safe to use in skincare?

Dimethyl Isosorbide has a Low concern rating from The Clean Sheet. Penetration enhancer for actives; plant-origin feedstock; low irritancy

Is Dimethyl Isosorbide allowed in India?

Dimethyl Isosorbide is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Dimethyl Isosorbide used for in cosmetics?

Dimethyl Isosorbide functions as: Solvent / Penetration enhancer. It is commonly found in: Serums, actives delivery systems.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)

Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made

Canada (NHPID)

Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS5306-85-4
EC226-159-8

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