The Clean Sheet
Ingredient Directory
Low ConcernVegan

Hesperidin

Hesperetin-7-O-rutinoside (citrus flavonoid glycoside)

Safety Notes

Citrus bioflavonoid with antioxidant, anti-inflammatory and capillary-supporting properties, used in soothing and antioxidant formulas, sometimes with other citrus flavonoids as a natural preservative-support blend.

Function & Common Use

Function

Antioxidant / Soothing / Skin conditioning

Category

Antioxidant

Common In

Antioxidant serums, soothing and brightening skincare

Origin

Natural (from citrus peel)

Concentration Limits

India (CDSCO)

No specific limit under CR 2020 in source checked

EU Cosmetics Reg.

No specific limit; use at self-determined safe level per safety assessment

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked

Baby restriction: None identified for standard cosmetic use

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Hesperidin safe to use in skincare?

Hesperidin has a Low concern rating from The Clean Sheet. Citrus bioflavonoid with antioxidant, anti-inflammatory and capillary-supporting properties, used in soothing and antioxidant formulas, sometimes with other citrus flavonoids as a natural preservative-support blend.

Is Hesperidin allowed in India?

Hesperidin is currently classified as "Permitted; regulated as a cosmetic ingredient under CR 2020" under Indian cosmetics regulations. The maximum permitted concentration is No specific limit under CR 2020 in source checked.

What is Hesperidin used for in cosmetics?

Hesperidin functions as: Antioxidant / Soothing / Skin conditioning. It is commonly found in: Antioxidant serums, soothing and brightening skincare.

Is Hesperidin safe for babies?

Hesperidin has baby/child restrictions: None identified for standard cosmetic use. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted; regulated as a cosmetic ingredient under CR 2020
EU
Permitted
US FDA
Permitted; no specific 21 CFR cosmetic restriction identified in source checked
Korea (MFDS)
Permitted; no specific MFDS restriction identified in source checked
Australia (TGA)
Cosmetic ingredient under AICIS; standard framework applies; no therapeutic listing unless therapeutic claims made
Canada (NHPID)
Not listed as restricted on Health Canada Cosmetic Ingredient Hotlist in source checked; standard cosmetic notification applies

Identifiers

CAS520-26-3
EC208-288-1

Want to check if your product contains Hesperidin?

Analyse a Product
WhatsApp Community

Join The Clean Sheet™ community

Science-backed beauty tips, ingredient alerts, and early access. Straight to your WhatsApp.

Join for free →