The Clean Sheet
Ingredient Directory
Medium ConcernVegan Evaluator Flag

Hinokitiol

beta-Thujaplicin (2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one)

Safety Notes

Naturally occurring tropolone with broad antimicrobial and antifungal activity, plus a chelating action on metal ions. Used at very low levels (roughly 0.01-0.1%). Effective in J-beauty and clean-preservation systems. Some cytotoxicity and metal-chelation data warrant conservative use levels; review supplier safety dossier.

Function & Common Use

Function

Antimicrobial / Preservative / Skin conditioning

Category

Preservative / Antimicrobial

Common In

Scalp and acne treatments, deodorants, natural preservative blends, oral care

Origin

Natural (from Chamaecyparis taiwanensis / hinoki cypress) or synthetic

Concentration Limits

India (CDSCO)

No specific limit under CR 2020 in source checked

EU Cosmetics Reg.

No specific limit; use at self-determined safe level per safety assessment

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked

Baby restriction: None identified for standard cosmetic use

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Hinokitiol safe to use in skincare?

Hinokitiol has a Medium concern rating. Naturally occurring tropolone with broad antimicrobial and antifungal activity, plus a chelating action on metal ions. Used at very low levels (roughly 0.01-0.1%). Effective in J-beauty and clean-preservation systems. Some cytotoxicity and metal-chelation data warrant conservative use levels; review supplier safety dossier.

Is Hinokitiol allowed in India?

Hinokitiol is currently classified as "Permitted; regulated as a cosmetic ingredient under CR 2020" under Indian cosmetics regulations. The maximum permitted concentration is No specific limit under CR 2020 in source checked.

What is Hinokitiol used for in cosmetics?

Hinokitiol functions as: Antimicrobial / Preservative / Skin conditioning. It is commonly found in: Scalp and acne treatments, deodorants, natural preservative blends, oral care.

Is Hinokitiol safe for babies?

Hinokitiol has baby/child restrictions: None identified for standard cosmetic use. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment
Medium Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)

Permitted; regulated as a cosmetic ingredient under CR 2020

EU
Permitted
US FDA

Permitted; no specific 21 CFR cosmetic restriction identified in source checked

Korea (MFDS)

Permitted; no specific MFDS restriction identified in source checked

Australia (TGA)

Cosmetic ingredient under AICIS; standard framework applies; no therapeutic listing unless therapeutic claims made

Canada (NHPID)

Not listed as restricted on Health Canada Cosmetic Ingredient Hotlist in source checked; standard cosmetic notification applies

Identifiers

CAS499-44-5
EC207-880-7

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