The Clean Sheet
Ingredient Directory
Low ConcernVegan

Lysine

L-Lysine / 2,6-Diaminohexanoic acid

Safety Notes

Essential amino acid; collagen crosslinking role; supports collagen synthesis when topically applied (penetration limited); hair strengthening; low sensitization risk

Function & Common Use

Function

Skin Conditioning / Hair Conditioning

Category

Conditioner

Common In

Hair care strengthening products serums

Origin

Synthetic / Fermentation

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked; EU limit reference: No

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Lysine safe to use in skincare?

Lysine has a Low concern rating from The Clean Sheet. Essential amino acid; collagen crosslinking role; supports collagen synthesis when topically applied (penetration limited); hair strengthening; low sensitization risk

Is Lysine allowed in India?

Lysine is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Lysine used for in cosmetics?

Lysine functions as: Skin Conditioning / Hair Conditioning. It is commonly found in: Hair care strengthening products serums.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)

Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made

Canada (NHPID)

Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS56-87-1
EC200-294-2

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