Ingredient Directory
Low ConcernVegan

Methylsulfonylmethane

Dimethyl sulfone; DMSO2

Safety Flags
Allergen: None identified
Safety Notes

Organosulfur compound used as dietary supplement and in topical formulations. CosIng-registered function as solvent and viscosity controller. No CMR or SVHC concerns. Clinical evidence for topical cosmetic efficacy claims is limited compared to oral use.

Function & Common Use

Function

Solvent / Viscosity controlling / Skin conditioning

Category

Functional Ingredient / Sulfur Compound

Common In

Joint-health topicals, scalp treatments, anti-inflammatory serums, skin conditioning products

Origin

Synthetic (also occurs naturally in trace amounts in some foods)

Concentration Limits

India (CDSCO)

Not verified in source checked

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No FDA maximum established; GRAS status for food

Korea (MFDS)

Not verified in source checked

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Methylsulfonylmethane safe to use in skincare?

Methylsulfonylmethane has a Low concern rating from The Clean Sheet. Organosulfur compound used as dietary supplement and in topical formulations. CosIng-registered function as solvent and viscosity controller. No CMR or SVHC concerns. Clinical evidence for topical cosmetic efficacy claims is limited compared to oral use.

Is Methylsulfonylmethane allowed in India?

Methylsulfonylmethane is currently classified as "Permitted cosmetic ingredient under Cosmetics Rules 2020" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.

What is Methylsulfonylmethane used for in cosmetics?

Methylsulfonylmethane functions as: Solvent / Viscosity controlling / Skin conditioning. It is commonly found in: Joint-health topicals, scalp treatments, anti-inflammatory serums, skin conditioning products.

Can Methylsulfonylmethane cause an allergic reaction?

Yes. Methylsulfonylmethane has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted cosmetic ingredient under Cosmetics Rules 2020
EU
Permitted; listed in EU CosIng inventory under EU Regulation 1223/2009; no Annex restriction
US FDA
Permitted cosmetic ingredient; GRAS status for food use
Korea (MFDS)
Permitted cosmetic ingredient
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS67-71-0
EC200-665-9

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