Ingredient Directory
Medium ConcernVegan Evaluator Flag

N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate

N1,N1-bis(2-hydroxyethyl)benzene-1,4-diamine sulfate

Safety Flags
Allergen: Yes
Safety Notes

p-Phenylenediamine derivative; carries cross-sensitization risk with PPD. Contact allergy potential. Label must carry appropriate hair dye allergy warning.

Function & Common Use

Function

Oxidative Hair Dye

Category

Hair Dyes

Common In

Permanent hair color

Origin

Synthetic

Concentration Limits

India (CDSCO)

Not explicitly specified; aligned with BIS IS 4707

EU Cosmetics Reg.

2.5% (calculated as the sulfate) in ready-to-use oxidative hair color

US FDA (21 CFR)

No federal limit specified

Korea (MFDS)

Restricted; MFDS safety standards apply

Format restriction: Oxidative use only; label warning required; patch test recommended

Baby restriction: Yes

Pregnancy: No

IFRA: No

Frequently Asked Questions

Is N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate safe to use in skincare?

N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate has a Medium concern rating. p-Phenylenediamine derivative; carries cross-sensitization risk with PPD. Contact allergy potential. Label must carry appropriate hair dye allergy warning.

Is N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate allowed in India?

N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate is currently classified as "Permitted" under Indian cosmetics regulations. The maximum permitted concentration is Not explicitly specified; aligned with BIS IS 4707.

What is N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate used for in cosmetics?

N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate functions as: Oxidative Hair Dye. It is commonly found in: Permanent hair color.

Can N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate cause an allergic reaction?

Yes. N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate has an allergen flag (Yes). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

Is N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate safe for babies?

N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate has baby/child restrictions: Yes. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment
Medium Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Restricted
US FDA
Permitted
Korea (MFDS)
Restricted
Australia (TGA)
Restricted
Canada (NHPID)
Restricted

EU Annex: Annex III (restricted)

Identifiers

CAS54381-16-7
EC259-134-7

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