Photolyase
DNA photolyase enzyme (typically from Anacystis nidulans or Micrococcus lysodeikticus)
Emerging ingredient - not a UV filter per regulatory definition but repairs UV-induced CPD (cyclobutane pyrimidine dimers) in DNA; not classified as sunscreen active in any major market; marketed under cosmetic claims; note: Diguanosine Tetraphosphate (Ap4G) is a separate DNA repair trigger, not an enzyme.
Function & Common Use
DNA repair enzyme; Skin conditioning; Adjunct UV protection
UV Filters
Post-sun repair serums, sunscreens with DNA repair claim, anti-aging after-sun products (e.g. Isdin Eryfotona)
Biotechnology (enzyme, microbial fermentation)
Concentration Limits
N/A
N/A (no regulatory UV filter status; used as cosmetic active)
N/A
N/A
Format restriction: Requires encapsulation (liposomes) for skin delivery; heat-sensitive enzyme
Baby restriction: No
Pregnancy: No
IFRA: No
Frequently Asked Questions
Is Photolyase safe to use in skincare?
Photolyase has a Low concern rating from The Clean Sheet. Emerging ingredient - not a UV filter per regulatory definition but repairs UV-induced CPD (cyclobutane pyrimidine dimers) in DNA; not classified as sunscreen active in any major market; marketed under cosmetic claims; note: Diguanosine Tetraphosphate (Ap4G) is a separate DNA repair trigger, not an enzyme.
Is Photolyase allowed in India?
Photolyase is currently classified as "Not listed" under Indian cosmetics regulations. The maximum permitted concentration is N/A.
What is Photolyase used for in cosmetics?
Photolyase functions as: DNA repair enzyme; Skin conditioning; Adjunct UV protection. It is commonly found in: Post-sun repair serums, sunscreens with DNA repair claim, anti-aging after-sun products (e.g. Isdin Eryfotona).
Can Photolyase cause an allergic reaction?
Yes. Photolyase has an allergen flag (No). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.
Is Photolyase safe for babies?
Photolyase has baby/child restrictions: No. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.
Regulatory Status
EU Annex: None
Identifiers
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