Low ConcernVegan

Polylysine

epsilon-Poly-L-lysine (natural cationic polypeptide)

Safety Notes

Fermentation-derived cationic polypeptide (epsilon-polylysine) with broad antimicrobial activity, used as a nature-derived preservative, usually alongside other hurdles. Effective across a useful pH range; performance can be reduced by anionic surfactants.

Function & Common Use

Function

Antimicrobial / Preservative (natural)

Concentration Limits

India (CDSCO)

No specific limit under CR 2020 in source checked

EU Cosmetics Reg.

No specific limit; use at self-determined safe level per safety assessment

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked

Baby restriction: None identified for standard cosmetic use

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Polylysine safe to use in skincare?

Polylysine has a Low concern rating from The Clean Sheet. Fermentation-derived cationic polypeptide (epsilon-polylysine) with broad antimicrobial activity, used as a nature-derived preservative, usually alongside other hurdles. Effective across a useful pH range; performance can be reduced by anionic surfactants.

Is Polylysine allowed in India?

Polylysine is currently classified as "Permitted; regulated as a cosmetic ingredient under CR 2020" under Indian cosmetics regulations. The maximum permitted concentration is No specific limit under CR 2020 in source checked.

What is Polylysine used for in cosmetics?

Polylysine functions as: Antimicrobial / Preservative (natural). It is commonly found in: Natural and organic skincare, COSMOS-type preservation systems.

Is Polylysine safe for babies?

Polylysine has baby/child restrictions: None identified for standard cosmetic use. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment

Low Concern

Data Confidence

Medium

Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.