The Clean Sheet
Ingredient Directory
Low ConcernVegan

Tetrasodium Glutamate Diacetate

Tetrasodium N,N-bis(carboxymethyl)-L-glutamate (GLDA)

Safety Notes

Readily biodegradable amino-acid-based chelator (GLDA) that sequesters metal ions to stabilise preservatives, antioxidants, colour and fragrance and to boost surfactant performance in hard water. A green replacement for EDTA.

Function & Common Use

Function

Chelating agent

Category

Chelating Agent

Common In

Cleansers, shampoos, creams; readily biodegradable EDTA alternative

Origin

Derived from L-glutamic acid (fermentation-based, e.g. from corn)

Concentration Limits

India (CDSCO)

No specific limit under CR 2020 in source checked

EU Cosmetics Reg.

No specific limit; use at self-determined safe level per safety assessment

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked

Baby restriction: None identified for standard cosmetic use

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Tetrasodium Glutamate Diacetate safe to use in skincare?

Tetrasodium Glutamate Diacetate has a Low concern rating from The Clean Sheet. Readily biodegradable amino-acid-based chelator (GLDA) that sequesters metal ions to stabilise preservatives, antioxidants, colour and fragrance and to boost surfactant performance in hard water. A green replacement for EDTA.

Is Tetrasodium Glutamate Diacetate allowed in India?

Tetrasodium Glutamate Diacetate is currently classified as "Permitted; regulated as a cosmetic ingredient under CR 2020" under Indian cosmetics regulations. The maximum permitted concentration is No specific limit under CR 2020 in source checked.

What is Tetrasodium Glutamate Diacetate used for in cosmetics?

Tetrasodium Glutamate Diacetate functions as: Chelating agent. It is commonly found in: Cleansers, shampoos, creams; readily biodegradable EDTA alternative.

Is Tetrasodium Glutamate Diacetate safe for babies?

Tetrasodium Glutamate Diacetate has baby/child restrictions: None identified for standard cosmetic use. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted; regulated as a cosmetic ingredient under CR 2020
EU
Permitted
US FDA
Permitted; no specific 21 CFR cosmetic restriction identified in source checked
Korea (MFDS)
Permitted; no specific MFDS restriction identified in source checked
Australia (TGA)
Cosmetic ingredient under AICIS; standard framework applies; no therapeutic listing unless therapeutic claims made
Canada (NHPID)
Not listed as restricted on Health Canada Cosmetic Ingredient Hotlist in source checked; standard cosmetic notification applies

Identifiers

CAS51981-21-6
EC257-573-7

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