Ingredient Directory
High ConcernVegan Evaluator Flag

Tretinoin

All-trans-retinoic acid; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

Safety Flags
CMR: Yes - Cat 2 (reproductive toxicity / teratogen)
Safety Notes

Potent teratogen - strictly contraindicated in pregnancy; banned in EU cosmetics (Annex II); prescription-only drug in India, US, and all major markets; causes photosensitivity, retinoid dermatitis.

Function & Common Use

Function

Keratolytic / Anti-acne / Anti-aging (Rx only)

Category

Vitamins

Common In

Prescription acne treatments, Rx anti-aging formulations (Retin-A, Tretiva cream)

Origin

Synthetic

Concentration Limits

India (CDSCO)

Not permitted in cosmetics; Schedule H prescription drug

EU Cosmetics Reg.

BANNED in cosmetics (Annex II, entry 369)

US FDA (21 CFR)

Not permitted in cosmetics; Rx drug product only

Korea (MFDS)

Not permitted in cosmetics; Rx prescription only

Format restriction: PRESCRIPTION ONLY in all markets; BANNED as cosmetic ingredient in EU; not for cosmetic use anywhere

Baby restriction: Yes

Pregnancy: Yes

IFRA: No

Frequently Asked Questions

Is Tretinoin safe to use in skincare?

Tretinoin has a High concern rating. Potent teratogen - strictly contraindicated in pregnancy; banned in EU cosmetics (Annex II); prescription-only drug in India, US, and all major markets; causes photosensitivity, retinoid dermatitis.

Is Tretinoin allowed in India?

Tretinoin is currently classified as "Restricted - Prescription Only Drug (Schedule H)" under Indian cosmetics regulations. The maximum permitted concentration is Not permitted in cosmetics; Schedule H prescription drug.

What is Tretinoin used for in cosmetics?

Tretinoin functions as: Keratolytic / Anti-acne / Anti-aging (Rx only). It is commonly found in: Prescription acne treatments, Rx anti-aging formulations (Retin-A, Tretiva cream).

Can Tretinoin cause an allergic reaction?

Yes. Tretinoin has an allergen flag (No). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

Is Tretinoin safe for babies?

Tretinoin has baby/child restrictions: Yes. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.

TCS Assessment
High Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Restricted - Prescription Only Drug (Schedule H)
EU
Banned
US FDA
Rx Only
Korea (MFDS)
Rx Only
Australia (TGA)
Prescription medicine (Schedule 4); not permitted in cosmetics
Canada (NHPID)
Prescription drug; not permitted as cosmetic ingredient

EU Annex: Annex II (banned)

Identifiers

CAS302-79-4
EC206-129-0

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