Ingredient Directory
Low ConcernVegan Evaluator Flag

Acetyl Tetrapeptide-5

Vialox-inspired depuffing peptide

Safety Notes

Tetrapeptide active for reducing eye puffiness; mechanism: reduces water retention and vascular permeability in periorbital area; clinical data largely from brand-commissioned research; well-tolerated; eye-area safe

Function & Common Use

Function

Active (anti-puffiness peptide)

Category

Active Ingredient

Common In

Eye creams depuffing serums

Origin

Synthetic

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Format restriction: Leave-on

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Acetyl Tetrapeptide-5 safe to use in skincare?

Acetyl Tetrapeptide-5 has a Low concern rating from The Clean Sheet. Tetrapeptide active for reducing eye puffiness; mechanism: reduces water retention and vascular permeability in periorbital area; clinical data largely from brand-commissioned research; well-tolerated; eye-area safe

Is Acetyl Tetrapeptide-5 allowed in India?

Acetyl Tetrapeptide-5 is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Acetyl Tetrapeptide-5 used for in cosmetics?

Acetyl Tetrapeptide-5 functions as: Active (anti-puffiness peptide). It is commonly found in: Eye creams depuffing serums.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)
Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made
Canada (NHPID)
Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS820959-17-9
ECN/A

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