Ingredient Directory
Low ConcernVegan Evaluator Flag

Dimethyl Sulfone

MSM / Methylsulfonylmethane

Safety Notes

Sulfur compound; anti-inflammatory; oral MSM has evidence for joint pain, topical cosmetic evidence weaker; skin conditioning; sulfur delivery; well-tolerated topically; claims substantiation required for skin claims

Function & Common Use

Function

Active (anti-inflammatory / joint support) / Skin Conditioning

Category

Active Ingredient

Common In

Anti-inflammatory serums joint care products

Origin

Synthetic

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Dimethyl Sulfone safe to use in skincare?

Dimethyl Sulfone has a Low concern rating from The Clean Sheet. Sulfur compound; anti-inflammatory; oral MSM has evidence for joint pain, topical cosmetic evidence weaker; skin conditioning; sulfur delivery; well-tolerated topically; claims substantiation required for skin claims

Is Dimethyl Sulfone allowed in India?

Dimethyl Sulfone is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Dimethyl Sulfone used for in cosmetics?

Dimethyl Sulfone functions as: Active (anti-inflammatory / joint support) / Skin Conditioning. It is commonly found in: Anti-inflammatory serums joint care products.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)
Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made
Canada (NHPID)
Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS67-71-0
EC200-665-9

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