Ingredient Directory
Low Concern

Hydroxyproline

Trans-4-hydroxy-L-proline; major component of collagen

Safety Flags
Allergen: None identified
Safety Notes

Constitutes approximately 13% of all amino acids in collagen. Vegan flag 'Depends on source' - can be fermented/synthetic, but is also commonly derived from animal collagen hydrolysis. Excellent safety profile.

Function & Common Use

Function

Skin conditioning / Humectant / Collagen marker and support

Category

Amino Acid

Common In

Anti-ageing serums, collagen-boosting moisturisers, skin repair products

Origin

Natural / Biotechnology

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

No limit

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Hydroxyproline safe to use in skincare?

Hydroxyproline has a Low concern rating from The Clean Sheet. Constitutes approximately 13% of all amino acids in collagen. Vegan flag 'Depends on source' - can be fermented/synthetic, but is also commonly derived from animal collagen hydrolysis. Excellent safety profile.

Is Hydroxyproline allowed in India?

Hydroxyproline is currently classified as "Permitted; amino acids are generally recognised as safe under Cosmetics Rules 2020; no restriction" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Hydroxyproline used for in cosmetics?

Hydroxyproline functions as: Skin conditioning / Humectant / Collagen marker and support. It is commonly found in: Anti-ageing serums, collagen-boosting moisturisers, skin repair products.

Can Hydroxyproline cause an allergic reaction?

Yes. Hydroxyproline has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted; amino acids are generally recognised as safe under Cosmetics Rules 2020; no restriction
EU
Permitted; listed in EU CosIng as skin conditioning agent; not restricted
US FDA
Permitted cosmetic ingredient; no restriction in 21 CFR
Korea (MFDS)
Permitted cosmetic ingredient; not listed as restricted or prohibited by MFDS
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS51-35-4
EC200-092-0

Want to check if your product contains Hydroxyproline?

Analyse a Product

More Amino Acid Ingredients

WhatsApp Community

Join The Clean Sheet™ community

Science-backed beauty tips, ingredient alerts, and early access. Straight to your WhatsApp.

Join for free →