Ingredient Directory
Low ConcernVegan

Lysine HCl

L-Lysine monohydrochloride (essential amino acid salt)

Safety Flags
Allergen: None identified
Safety Notes

HCl salt of L-Lysine; more stable and water-soluble than free base. Essential amino acid critical for collagen cross-linking via lysyl oxidase pathway. HCl counterion is benign at cosmetic concentrations.

Function & Common Use

Function

Skin conditioning / Antistatic / Hair conditioning / Supports collagen cross-linking

Category

Amino Acid

Common In

Hair care products, moisturisers, skin conditioning serums, amino acid complex formulations

Origin

Natural / Biotechnology

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

No limit

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Lysine HCl safe to use in skincare?

Lysine HCl has a Low concern rating from The Clean Sheet. HCl salt of L-Lysine; more stable and water-soluble than free base. Essential amino acid critical for collagen cross-linking via lysyl oxidase pathway. HCl counterion is benign at cosmetic concentrations.

Is Lysine HCl allowed in India?

Lysine HCl is currently classified as "Permitted; amino acids are generally recognised as safe under Cosmetics Rules 2020; no restriction" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Lysine HCl used for in cosmetics?

Lysine HCl functions as: Skin conditioning / Antistatic / Hair conditioning / Supports collagen cross-linking. It is commonly found in: Hair care products, moisturisers, skin conditioning serums, amino acid complex formulations.

Can Lysine HCl cause an allergic reaction?

Yes. Lysine HCl has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted; amino acids are generally recognised as safe under Cosmetics Rules 2020; no restriction
EU
Permitted; listed in EU CosIng as skin conditioning and antistatic agent; not restricted
US FDA
GRAS as food additive; permitted cosmetic ingredient; no restriction in 21 CFR
Korea (MFDS)
Permitted cosmetic ingredient; not listed as restricted or prohibited by MFDS
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS657-27-2
EC211-519-9

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