Ingredient Directory
Low ConcernVegan

Leuphasyl (Dipeptide-2)

Dipeptide-2 / Leuphasyl

Safety Notes

Enkephalin analogue; reduces fluid accumulation in periorbital area; anti-puffiness; clinical evidence for eye bag reduction; well-tolerated; often combined with acetyl tetrapeptide-5

Function & Common Use

Function

Active (anti-wrinkle / anti-puffiness peptide)

Category

Active Ingredient

Common In

Eye creams anti-puffiness serums

Origin

Synthetic

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Leuphasyl (Dipeptide-2) safe to use in skincare?

Leuphasyl (Dipeptide-2) has a Low concern rating from The Clean Sheet. Enkephalin analogue; reduces fluid accumulation in periorbital area; anti-puffiness; clinical evidence for eye bag reduction; well-tolerated; often combined with acetyl tetrapeptide-5

Is Leuphasyl (Dipeptide-2) allowed in India?

Leuphasyl (Dipeptide-2) is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Leuphasyl (Dipeptide-2) used for in cosmetics?

Leuphasyl (Dipeptide-2) functions as: Active (anti-wrinkle / anti-puffiness peptide). It is commonly found in: Eye creams anti-puffiness serums.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)
Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made
Canada (NHPID)
Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS162698-40-0
ECN/A

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