Ingredient Directory
Low ConcernVegan Evaluator Flag

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine

SYN-AKE / Snake venom peptide mimic

Safety Notes

Synthetic peptide mimicking Waglerin-1 (viper venom component); antagonises neuromuscular acetylcholine receptor; topical claims of reducing expression wrinkles; clinical data from EMV Ingredients; well-tolerated; no actual venom or biological material

Function & Common Use

Function

Active (anti-wrinkle peptide)

Category

Active Ingredient

Common In

Botox-alternative serums expression line products

Origin

Synthetic

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine safe to use in skincare?

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine has a Low concern rating from The Clean Sheet. Synthetic peptide mimicking Waglerin-1 (viper venom component); antagonises neuromuscular acetylcholine receptor; topical claims of reducing expression wrinkles; clinical data from EMV Ingredients; well-tolerated; no actual venom or biological material

Is Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine allowed in India?

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine used for in cosmetics?

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine functions as: Active (anti-wrinkle peptide). It is commonly found in: Botox-alternative serums expression line products.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)
Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made
Canada (NHPID)
Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CASN/A
ECN/A

Want to check if your product contains Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine?

Analyse a Product
WhatsApp Community

Join The Clean Sheet™ community

Science-backed beauty tips, ingredient alerts, and early access. Straight to your WhatsApp.

Join for free →