Ingredient Directory
Low ConcernVegan

Proline

L-Proline / Pyrrolidine-2-carboxylic acid

Safety Notes

Imino acid; major component of collagen structure; NMF component; humectant; supports collagen fibre formation

Function & Common Use

Function

Skin Conditioning / Moisturising

Category

Conditioner

Common In

Moisturisers anti-aging serums skin conditioning products

Origin

Synthetic / Fermentation

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Proline safe to use in skincare?

Proline has a Low concern rating from The Clean Sheet. Imino acid; major component of collagen structure; NMF component; humectant; supports collagen fibre formation

Is Proline allowed in India?

Proline is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Proline used for in cosmetics?

Proline functions as: Skin Conditioning / Moisturising. It is commonly found in: Moisturisers anti-aging serums skin conditioning products.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)
Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made
Canada (NHPID)
Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS147-85-3
EC205-702-2

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