Low ConcernVegan

Serine

L-Serine / 2-Amino-3-hydroxypropanoic acid

Safety Notes

NMF component (~7% of NMF); humectant; phospholipid precursor; supports skin lipid barrier synthesis

Function & Common Use

Function

Skin Conditioning / Moisturising

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Serine safe to use in skincare?

Serine has a Low concern rating from The Clean Sheet. NMF component (~7% of NMF); humectant; phospholipid precursor; supports skin lipid barrier synthesis

Is Serine allowed in India?

Serine is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Serine used for in cosmetics?

Serine functions as: Skin Conditioning / Moisturising. It is commonly found in: Moisturisers amino acid serums NMF mimicking products.

TCS Assessment

Low Concern

Data Confidence

High

Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)

Permitted

US FDA

Permitted

Korea (MFDS)

Permitted

Australia (TGA)

Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made

Canada (NHPID)

Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS56-45-1

EC200-274-3

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