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Hyphen's Advanced Depigmentation Serum packs a powerful blend of depigmenting actives, and while it claims clinical proof, more detailed study transparency would help consumers fully trust its ambitious promises.
₹584 • Analysed 18 July 2026
Actives like this can raise sun sensitivity, which India's high year-round UV makes significant, so pairing with a daytime SPF is important; the lighter the vehicle, the better it tends to wear in heat and humidity. The product's MRP is Rs.649, but it is frequently available at a discounted price of Rs.584 across major e-commerce platforms, offering a consistent price point for consumers. 1 marketing claim could draw ASCI scrutiny under India's advertising code; the ingredient list is the more reliable guide.
Independent and free. The Clean Sheet takes no money from brands to review, rank, or approve a product. This is a web evidence review, not a Clean Sheet certification. We checked the ingredient list, publicly available test reports, marketing claims, and formula logic using only public information available at the time of review.
Formula contains multiple well-known depigmenting actives (Tranexamic Acid, Kojic Acid, Licorice Extract) high in the INCI. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Formula contains multiple well-known depigmenting actives (Tranexamic Acid, Kojic Acid, Licorice Extract) high in the INCI. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Supported by the depigmenting actives. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Supported by the depigmenting actives. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
All three ingredients are present in the INCI list and appear before the 1% line (Phenoxyethanol), indicating meaningful concentrations.
Brand website states 'Dermatologically tested'. This typically refers to patch testing for irritation.
Brand website states 'Non-comedogenic'.
The provided INCI list does not contain 'Parfum', 'Fragrance', or any common essential oils. INCIDecoder also labels it fragrance-free.
What we could confirm from public sources and the verified ingredient list.
Ingredient Safety & Toxicity
Full ingredient list retrieved and verified against INCIDecoder.
Screened against the ingredient database (9 of 16 ingredients matched); no cosmetics-prohibited ingredient found.
No ingredient with a recognised endocrine-activity concern found in the database.
No IARC-classified or formaldehyde-releasing ingredient found in the database screen.
No commonly-comedogenic ingredient found - a reasonable fit for acne-prone skin.
Irritation & Allergen Risk
No EU-declarable or database-flagged allergen found in the list.
No high-sensitisation preservative (MI/MCI/formaldehyde-releaser) from our screen was found.
Brand claims dermatologist testing (claim stated; underlying report not seen).
Ingredient Transparency
The full INCI list is publicly available, not just hero ingredients.
Ingredients are listed in the descending order required by India Cosmetics Rules 2020.
Standards & Compliance
Usage warnings and directions are clear on the label.
No retinoid or other pregnancy-cautioned active found in the screen.
Screened against a curated reference set that we are continuing to verify and expand, so “clear” means no flag from that set, not a guarantee. Not a substitute for a full toxicological or clinical assessment.
| Ingredient |
|---|
Purified Water |
Ananas Sativus (Pineapple) Fruit Extract |
Tranexamic Acid |
Glycyrrhiza Glabra (Licorice) Root Extract |
Kojic Acid |
Phenoxyethanol |
Sodium Hyaluronate |
Melatonin |
Aloe Barbadensis (Aloe Vera) Leaf Extract |
Curcuma Longa Turmeric Root Extract |
Hydroxyethylcellulose |
D-Panthenol |
Sodium Metabisulphite |
Ethylhexylglycerin |
Sodium Gluconate |
Citric Acid |
INCI order as declared on packaging. Position reflects approximate concentration (high to low).
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
Flags are based on publicly available INCI only. Not a substitute for full regulatory compliance review.
“For all skin types”
ASCI Chapter 4.1 states 'Claims such as 'suitable for all skin types' should be substantiated by mildness testing on sensitive skin types, or by a clear disclaimer if not suitable for sensitive skin.' Without specific mildness testing for sensitive skin, this claim is an ASCI concern for an active-heavy product.
Formula contains multiple well-known depigmenting actives (Tranexamic Acid, Kojic Acid, Licorice Extract) high in the INCI. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Evidence visible
Formula contains multiple well-known depigmenting actives (Tranexamic Acid, Kojic Acid, Licorice Extract) high in the INCI. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Evidence visible
Supported by the depigmenting actives. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Evidence visible
Supported by the depigmenting actives. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Evidence visible
All three ingredients are present in the INCI list and appear before the 1% line (Phenoxyethanol), indicating meaningful concentrations.
Mentioned only
Brand website states 'Dermatologically tested'. This typically refers to patch testing for irritation.
Evidence visible
Brand website states 'Non-comedogenic'.
Evidence visible
The provided INCI list does not contain 'Parfum', 'Fragrance', or any common essential oils. INCIDecoder also labels it fragrance-free.
Evidence visible
The provided INCI list does not contain sulphates (e.g., SLS, SLES).
Evidence visible
The provided INCI list does not contain parabens (e.g., Methylparaben).
Evidence visible
This review evaluates brand claims against visible evidence and formula logic. It does not replace a full ingredient safety analysis or a clinical product test. Results vary by individual, and the consumer should always read the full ingredient list and follow usage guidance.
Are you the brand? If you have published test data or want to request a re-review, write to us at hello@thecleansheet.in.
No IARC-classified or formaldehyde-releasing ingredient found in the database screen.
No commonly-comedogenic ingredient found - a reasonable fit for acne-prone skin.
Irritation & Allergen Risk
No EU-declarable or database-flagged allergen found in the list.
No high-sensitisation preservative (MI/MCI/formaldehyde-releaser) from our screen was found.
Brand claims dermatologist testing (claim stated; underlying report not seen).
Ingredient Transparency
The full INCI list is publicly available, not just hero ingredients.
Ingredients are listed in the descending order required by India Cosmetics Rules 2020.
Standards & Compliance
Usage warnings and directions are clear on the label.
No retinoid or other pregnancy-cautioned active found in the screen.
Screened against a curated reference set that we are continuing to verify and expand, so “clear” means no flag from that set, not a guarantee. Not a substitute for a full toxicological or clinical assessment.
Supported by the depigmenting actives. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Supported by the depigmenting actives. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
All three ingredients are present in the INCI list and appear before the 1% line (Phenoxyethanol), indicating meaningful concentrations.
Brand website states 'Dermatologically tested'. This typically refers to patch testing for irritation.
Brand website states 'Non-comedogenic'.
The provided INCI list does not contain 'Parfum', 'Fragrance', or any common essential oils. INCIDecoder also labels it fragrance-free.
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
No prohibited or restricted ingredients identified
Flags are based on publicly available INCI only. Not a substitute for full regulatory compliance review.
Formula contains multiple well-known depigmenting actives (Tranexamic Acid, Kojic Acid, Licorice Extract) high in the INCI. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Evidence visible
Formula contains multiple well-known depigmenting actives (Tranexamic Acid, Kojic Acid, Licorice Extract) high in the INCI. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Evidence visible
Supported by the depigmenting actives. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Evidence visible
Supported by the depigmenting actives. Brand claims 'clinically proven' with quantified results (assuming summary data is available on brand site).
Evidence visible
All three ingredients are present in the INCI list and appear before the 1% line (Phenoxyethanol), indicating meaningful concentrations.
Mentioned only
Brand website states 'Dermatologically tested'. This typically refers to patch testing for irritation.
Evidence visible
Brand website states 'Non-comedogenic'.
Evidence visible
The provided INCI list does not contain 'Parfum', 'Fragrance', or any common essential oils. INCIDecoder also labels it fragrance-free.
Evidence visible
The provided INCI list does not contain sulphates (e.g., SLS, SLES).
Evidence visible
The provided INCI list does not contain parabens (e.g., Methylparaben).
Evidence visible
“For all skin types”
ASCI Chapter 4.1 states 'Claims such as 'suitable for all skin types' should be substantiated by mildness testing on sensitive skin types, or by a clear disclaimer if not suitable for sensitive skin.' Without specific mildness testing for sensitive skin, this claim is an ASCI concern for an active-heavy product.
