The Clean Sheet
Ingredient Directory
Low ConcernVegan

Ectoin

1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid

Safety Notes

Compatible solute from halophilic bacteria; protects cell membranes from stress; strong clinical evidence for irritant contact dermatitis atopic eczema sun stress; anti-inflammatory; membrane protective; well tolerated; very low sensitization risk; growing clinical evidence base

Function & Common Use

Function

Active (skin-protecting / anti-inflammatory)

Category

Active Ingredient

Common In

Sensitive skin products allergy care barrier repair serums

Origin

Biotechnological (bacterial fermentation)

Concentration Limits

India (CDSCO)

No limit

EU Cosmetics Reg.

No limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked; EU limit reference: None

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Ectoin safe to use in skincare?

Ectoin has a Low concern rating from The Clean Sheet. Compatible solute from halophilic bacteria; protects cell membranes from stress; strong clinical evidence for irritant contact dermatitis atopic eczema sun stress; anti-inflammatory; membrane protective; well tolerated; very low sensitization risk; growing clinical evidence base

Is Ectoin allowed in India?

Ectoin is currently classified as "Permitted" under Indian cosmetics regulations. No concentration limit is specified for India.

What is Ectoin used for in cosmetics?

Ectoin functions as: Active (skin-protecting / anti-inflammatory). It is commonly found in: Sensitive skin products allergy care barrier repair serums.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)

Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made

Canada (NHPID)

Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS96702-03-3
ECN/A

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