Hexetidine
5-Amino-1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine
Broad-spectrum antimicrobial effective against gram-positive and gram-negative bacteria and fungi; well-tolerated in oral care applications; not widely used in rinse-off skin products.
Function & Common Use
Preservative, Oral care antimicrobial, Deodorant active
Preservatives
Mouthwash, oral rinses, deodorants, antiseptic throat sprays
Synthetic
Concentration Limits
0.1%
0.1%
None (not in FDA cosmetic or OTC monograph)
0.1%
Format restriction: None; primarily used in oral care and deodorant products
Baby restriction: No
Pregnancy: No
IFRA: No
Frequently Asked Questions
Is Hexetidine safe to use in skincare?
Hexetidine has a Medium concern rating. Broad-spectrum antimicrobial effective against gram-positive and gram-negative bacteria and fungi; well-tolerated in oral care applications; not widely used in rinse-off skin products.
Is Hexetidine allowed in India?
Hexetidine is currently classified as "Permitted" under Indian cosmetics regulations. The maximum permitted concentration is 0.1%.
What is Hexetidine used for in cosmetics?
Hexetidine functions as: Preservative, Oral care antimicrobial, Deodorant active. It is commonly found in: Mouthwash, oral rinses, deodorants, antiseptic throat sprays.
Can Hexetidine cause an allergic reaction?
Yes. Hexetidine has an allergen flag (No). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.
Is Hexetidine safe for babies?
Hexetidine has baby/child restrictions: No. Avoid using products containing this ingredient on infants unless specifically formulated and labelled for baby use.
Regulatory Status
EU Annex: Annex V (permitted preservative)
Identifiers
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