The Clean Sheet
Ingredient Directory
Low ConcernVegan

Gluconolactone

D-Glucono-1,5-lactone

Safety Notes

Polyhydroxy acid (PHA), gentler than AHAs; does not penetrate as deeply; antioxidant properties; humectant effect; well-tolerated by rosacea and sensitive skin; chelating properties; no photosensitivity concern at cosmetic concentrations

Function & Common Use

Function

Active (PHA exfoliant) / Antioxidant

Category

Active Ingredient

Common In

Sensitive skin exfoliants toners serums

Origin

Synthetic / Fermentation

Concentration Limits

India (CDSCO)

No formal limit

EU Cosmetics Reg.

No specific limit

US FDA (21 CFR)

No specific 21 CFR cosmetic limit identified in source checked; EU limit reference: No

Korea (MFDS)

No specific MFDS limit identified in source checked; verify if ingredient is used in a Korean functional cosmetic category

Pregnancy: No specific restriction identified in source checked; standard cosmetic use

Frequently Asked Questions

Is Gluconolactone safe to use in skincare?

Gluconolactone has a Low concern rating from The Clean Sheet. Polyhydroxy acid (PHA), gentler than AHAs; does not penetrate as deeply; antioxidant properties; humectant effect; well-tolerated by rosacea and sensitive skin; chelating properties; no photosensitivity concern at cosmetic concentrations

Is Gluconolactone allowed in India?

Gluconolactone is currently classified as "Permitted" under Indian cosmetics regulations. The maximum permitted concentration is No formal limit.

What is Gluconolactone used for in cosmetics?

Gluconolactone functions as: Active (PHA exfoliant) / Antioxidant. It is commonly found in: Sensitive skin exfoliants toners serums.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Permitted
EU
Permitted
US FDA
Permitted
Korea (MFDS)
Permitted
Australia (TGA)

Cosmetic ingredient; standard TGA cosmetic framework applies; no therapeutic goods listing required unless therapeutic claims are made

Canada (NHPID)

Not specifically listed as restricted cosmetic ingredient in NHPID source checked; standard Health Canada cosmetic notification applies

Identifiers

CAS90-80-2
EC202-016-5

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