Ingredient Directory
Low ConcernVegan

Acetyl Octapeptide-3

Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (SNAP-8; extended Argireline analogue)

Safety Flags
Allergen: None identified
Safety Notes

SNAP-8 is marketed as an improved version of Argireline. Well-tolerated at typical use concentrations (0.001-0.01%). No sensitisation or systemic toxicity concerns at cosmetic doses.

Function & Common Use

Function

Skin conditioning / Anti-ageing / Expression line reduction

Category

Peptide / Anti-Ageing

Common In

Anti-wrinkle serums, expression line treatments (marketed as SNAP-8 by Lipotec/Lubrizol)

Origin

Synthetic

Concentration Limits

India (CDSCO)

Not verified in source checked

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

Not verified in source checked

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Acetyl Octapeptide-3 safe to use in skincare?

Acetyl Octapeptide-3 has a Low concern rating from The Clean Sheet. SNAP-8 is marketed as an improved version of Argireline. Well-tolerated at typical use concentrations (0.001-0.01%). No sensitisation or systemic toxicity concerns at cosmetic doses.

Is Acetyl Octapeptide-3 allowed in India?

Acetyl Octapeptide-3 is currently classified as "Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.

What is Acetyl Octapeptide-3 used for in cosmetics?

Acetyl Octapeptide-3 functions as: Skin conditioning / Anti-ageing / Expression line reduction. It is commonly found in: Anti-wrinkle serums, expression line treatments (marketed as SNAP-8 by Lipotec/Lubrizol).

Can Acetyl Octapeptide-3 cause an allergic reaction?

Yes. Acetyl Octapeptide-3 has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission
EU
Permitted; listed in EU CosIng as skin conditioning agent; not restricted
US FDA
Permitted cosmetic ingredient; not listed as prohibited or restricted in 21 CFR
Korea (MFDS)
Not listed as restricted or prohibited by MFDS; permitted cosmetic ingredient
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS868844-74-0
ECNot assigned

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