The Clean Sheet™
Ingredient Directory
Low ConcernVegan

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Diacetate salt of diaminobutyroyl benzylamide dipeptide (Leuphasyl)

Safety Flags
Allergen: None identified
Safety Notes

Marketed as Leuphasyl; claimed to act synergistically with Acetyl Hexapeptide-3. Safety profile acceptable at typical use concentrations (up to 0.004%).

Function & Common Use

Function

Skin conditioning / Anti-ageing / Expression line reduction

Category

Peptide / Anti-Ageing

Common In

Expression line serums, anti-wrinkle creams, eye contour treatments (Leuphasyl by Lipotec/Lubrizol)

Origin

Synthetic

Concentration Limits

India (CDSCO)

Not verified in source checked

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

Not verified in source checked

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Dipeptide Diaminobutyroyl Benzylamide Diacetate safe to use in skincare?

Dipeptide Diaminobutyroyl Benzylamide Diacetate has a Low concern rating from The Clean Sheet. Marketed as Leuphasyl; claimed to act synergistically with Acetyl Hexapeptide-3. Safety profile acceptable at typical use concentrations (up to 0.004%).

Is Dipeptide Diaminobutyroyl Benzylamide Diacetate allowed in India?

Dipeptide Diaminobutyroyl Benzylamide Diacetate is currently classified as "Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.

What is Dipeptide Diaminobutyroyl Benzylamide Diacetate used for in cosmetics?

Dipeptide Diaminobutyroyl Benzylamide Diacetate functions as: Skin conditioning / Anti-ageing / Expression line reduction. It is commonly found in: Expression line serums, anti-wrinkle creams, eye contour treatments (Leuphasyl by Lipotec/Lubrizol).

Can Dipeptide Diaminobutyroyl Benzylamide Diacetate cause an allergic reaction?

Yes. Dipeptide Diaminobutyroyl Benzylamide Diacetate has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission
EU
Permitted; listed in EU CosIng as skin conditioning agent; not restricted
US FDA
Permitted cosmetic ingredient; not listed as prohibited or restricted in 21 CFR
Korea (MFDS)
Not listed as restricted or prohibited by MFDS; permitted cosmetic ingredient
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS823202-99-9
ECNot assigned

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More Peptide / Anti-Ageing Ingredients

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Hexapeptide-10
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Oligopeptide-1
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Acetyl Octapeptide-3
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