The Clean Sheet™
Ingredient Directory
Low ConcernVegan

Oligopeptide-1

Recombinant human epidermal growth factor (hEGF); 53-amino acid polypeptide

Safety Flags
Allergen: Potential for hypersensitivity reactions in sensitive individuals; protein allergenicity possible at higher concentrations
Safety Notes

Recombinant human EGF. Topical absorption is limited; proliferative concern is theoretical at cosmetic doses. Claims of wound healing or cellular regeneration may trigger drug classification in some jurisdictions. Regulatory scrutiny advised for label claims.

Function & Common Use

Function

Skin conditioning / Cell proliferation stimulation / Wound healing support / Anti-ageing

Category

Peptide / Anti-Ageing

Common In

Anti-ageing serums, skin regeneration ampoules, post-procedure skincare, K-beauty EGF products

Origin

Biotechnology (recombinant)

Concentration Limits

India (CDSCO)

Not verified in source checked

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

Not verified in source checked

Pregnancy: No specific restriction identified; precautionary avoidance sometimes recommended due to cell proliferation mechanism

Frequently Asked Questions

Is Oligopeptide-1 safe to use in skincare?

Oligopeptide-1 has a Low concern rating from The Clean Sheet. Recombinant human EGF. Topical absorption is limited; proliferative concern is theoretical at cosmetic doses. Claims of wound healing or cellular regeneration may trigger drug classification in some jurisdictions. Regulatory scrutiny advised for label claims.

Is Oligopeptide-1 allowed in India?

Oligopeptide-1 is currently classified as "Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission; growth factors not specifically regulated as cosmetics in India" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.

What is Oligopeptide-1 used for in cosmetics?

Oligopeptide-1 functions as: Skin conditioning / Cell proliferation stimulation / Wound healing support / Anti-ageing. It is commonly found in: Anti-ageing serums, skin regeneration ampoules, post-procedure skincare, K-beauty EGF products.

Can Oligopeptide-1 cause an allergic reaction?

Yes. Oligopeptide-1 has an allergen flag (Potential for hypersensitivity reactions in sensitive individuals; protein allergenicity possible at higher concentrations). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission; growth factors not specifically regulated as cosmetics in India
EU
Permitted in EU as cosmetic ingredient; EU CosIng listed; not on restricted annexes
US FDA
Permitted cosmetic ingredient at low concentrations; FDA notes EGF products making drug-like wound-healing claims may require drug approval
Korea (MFDS)
Permitted; Korea MFDS has specific guidelines for EGF cosmetics; used in functional cosmetics for skin regeneration
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS62253-63-8
ECNot assigned

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