Ingredient Directory
Low ConcernVegan

Hexapeptide-10

Ser-Ile-Lys-Val-Ala-Val (laminin-derived hexapeptide; Serilesine)

Safety Flags
Allergen: None identified
Safety Notes

Derived from laminin sequence. Promotes adhesion between epidermis and dermis. Well-tolerated in safety studies.

Function & Common Use

Function

Skin conditioning / Skin firmness / Anti-ageing

Category

Peptide / Anti-Ageing

Common In

Firming serums, anti-ageing moisturisers, skin-lifting formulations (Serilesine by Lipotec/Lubrizol)

Origin

Synthetic

Concentration Limits

India (CDSCO)

Not verified in source checked

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

Not verified in source checked

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Hexapeptide-10 safe to use in skincare?

Hexapeptide-10 has a Low concern rating from The Clean Sheet. Derived from laminin sequence. Promotes adhesion between epidermis and dermis. Well-tolerated in safety studies.

Is Hexapeptide-10 allowed in India?

Hexapeptide-10 is currently classified as "Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.

What is Hexapeptide-10 used for in cosmetics?

Hexapeptide-10 functions as: Skin conditioning / Skin firmness / Anti-ageing. It is commonly found in: Firming serums, anti-ageing moisturisers, skin-lifting formulations (Serilesine by Lipotec/Lubrizol).

Can Hexapeptide-10 cause an allergic reaction?

Yes. Hexapeptide-10 has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission
EU
Permitted; listed in EU CosIng as skin conditioning agent; not restricted
US FDA
Permitted cosmetic ingredient; not listed as prohibited or restricted in 21 CFR
Korea (MFDS)
Not listed as restricted or prohibited by MFDS; permitted cosmetic ingredient
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS146439-94-3
ECNot assigned

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