Ingredient Directory
Low ConcernVegan

Tripeptide-1

Gly-His-Lys (glycyl-L-histidyl-L-lysine; GHK free peptide without copper)

Safety Flags
Allergen: None identified
Safety Notes

Naturally occurring tripeptide found in human plasma. The copper-free form (GHK) is also biologically active. Excellent safety profile; endogenous molecule.

Function & Common Use

Function

Skin conditioning / Anti-ageing / Collagen synthesis stimulation

Category

Peptide / Anti-Ageing

Common In

Anti-ageing serums, collagen-boosting creams, skin repair formulations

Origin

Synthetic

Concentration Limits

India (CDSCO)

Not verified in source checked

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

Not verified in source checked

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Tripeptide-1 safe to use in skincare?

Tripeptide-1 has a Low concern rating from The Clean Sheet. Naturally occurring tripeptide found in human plasma. The copper-free form (GHK) is also biologically active. Excellent safety profile; endogenous molecule.

Is Tripeptide-1 allowed in India?

Tripeptide-1 is currently classified as "Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.

What is Tripeptide-1 used for in cosmetics?

Tripeptide-1 functions as: Skin conditioning / Anti-ageing / Collagen synthesis stimulation. It is commonly found in: Anti-ageing serums, collagen-boosting creams, skin repair formulations.

Can Tripeptide-1 cause an allergic reaction?

Yes. Tripeptide-1 has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
High
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission
EU
Permitted; listed in EU CosIng; not restricted or prohibited
US FDA
Permitted cosmetic ingredient; not listed as prohibited or restricted in 21 CFR
Korea (MFDS)
Not listed as restricted or prohibited by MFDS; permitted cosmetic ingredient
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS72957-37-0
ECNot assigned

Want to check if your product contains Tripeptide-1?

Analyse a Product
WhatsApp Community

Join The Clean Sheet™ community

Science-backed beauty tips, ingredient alerts, and early access. Straight to your WhatsApp.

Join for free →