Palmitoyl Pentapeptide-4
Palmitoyl-Lys-Thr-Thr-Lys-Ser (Matrixyl; palmitic acid conjugated pentapeptide)
One of the most extensively studied cosmetic peptides; multiple published clinical studies. Well-tolerated at use concentrations of 0.0001-0.002%. No sensitisation, phototoxicity, or endocrine concerns identified.
Function & Common Use
Skin conditioning / Anti-ageing / Collagen and hyaluronic acid synthesis stimulation
Peptide / Anti-Ageing
Anti-ageing serums, moisturisers, eye creams (original Matrixyl by Sederma/Croda)
Synthetic
Concentration Limits
Not verified in source checked
No specific maximum
No specific maximum
Not verified in source checked
Pregnancy: No specific restriction identified
Frequently Asked Questions
Is Palmitoyl Pentapeptide-4 safe to use in skincare?
Palmitoyl Pentapeptide-4 has a Low concern rating from The Clean Sheet. One of the most extensively studied cosmetic peptides; multiple published clinical studies. Well-tolerated at use concentrations of 0.0001-0.002%. No sensitisation, phototoxicity, or endocrine concerns identified.
Is Palmitoyl Pentapeptide-4 allowed in India?
Palmitoyl Pentapeptide-4 is currently classified as "Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.
What is Palmitoyl Pentapeptide-4 used for in cosmetics?
Palmitoyl Pentapeptide-4 functions as: Skin conditioning / Anti-ageing / Collagen and hyaluronic acid synthesis stimulation. It is commonly found in: Anti-ageing serums, moisturisers, eye creams (original Matrixyl by Sederma/Croda).
Can Palmitoyl Pentapeptide-4 cause an allergic reaction?
Yes. Palmitoyl Pentapeptide-4 has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.
Regulatory Status
EU Annex: None
Identifiers
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