Ingredient Directory
Low ConcernVegan

Caprooyl Tetrapeptide-3

Hexanoyl-Gly-Gln-Pro-Arg (caproic acid conjugated tetrapeptide)

Safety Flags
Allergen: None identified
Safety Notes

Structurally related to Palmitoyl Tetrapeptide-7 but with shorter acyl chain. Well-tolerated at typical cosmetic use concentrations. Limited independent published safety data.

Function & Common Use

Function

Skin conditioning / Anti-ageing / Anti-inflammatory / Eye contour treatment

Category

Peptide / Anti-Ageing

Common In

Eye creams, anti-ageing serums targeting dark circles and glycation

Origin

Synthetic

Concentration Limits

India (CDSCO)

Not verified in source checked

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

Not verified in source checked

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Caprooyl Tetrapeptide-3 safe to use in skincare?

Caprooyl Tetrapeptide-3 has a Low concern rating from The Clean Sheet. Structurally related to Palmitoyl Tetrapeptide-7 but with shorter acyl chain. Well-tolerated at typical cosmetic use concentrations. Limited independent published safety data.

Is Caprooyl Tetrapeptide-3 allowed in India?

Caprooyl Tetrapeptide-3 is currently classified as "Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.

What is Caprooyl Tetrapeptide-3 used for in cosmetics?

Caprooyl Tetrapeptide-3 functions as: Skin conditioning / Anti-ageing / Anti-inflammatory / Eye contour treatment. It is commonly found in: Eye creams, anti-ageing serums targeting dark circles and glycation.

Can Caprooyl Tetrapeptide-3 cause an allergic reaction?

Yes. Caprooyl Tetrapeptide-3 has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission
EU
Permitted; listed in EU CosIng as skin conditioning agent; not restricted
US FDA
Permitted cosmetic ingredient; not listed as prohibited or restricted in 21 CFR
Korea (MFDS)
Not listed as restricted or prohibited by MFDS; permitted cosmetic ingredient
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS1174628-03-5
ECNot assigned

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