Ingredient Directory
Low ConcernVegan

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

Palmitoyl-Val-Dab (Vialox; palmitic acid conjugated dipeptide with diaminohydroxybutyrate)

Safety Flags
Allergen: None identified
Safety Notes

At cosmetic concentrations (0.005%), topical effect is local and reversible. No systemic safety concern. Well-tolerated in safety studies.

Function & Common Use

Function

Skin conditioning / Anti-ageing / Expression line reduction

Category

Peptide / Anti-Ageing

Common In

Anti-wrinkle serums, expression line creams (Vialox by Pentapharm/DSM)

Origin

Synthetic

Concentration Limits

India (CDSCO)

Not verified in source checked

EU Cosmetics Reg.

No specific maximum

US FDA (21 CFR)

No specific maximum

Korea (MFDS)

Not verified in source checked

Pregnancy: No specific restriction identified

Frequently Asked Questions

Is Palmitoyl Dipeptide-5 Diaminohydroxybutyrate safe to use in skincare?

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate has a Low concern rating from The Clean Sheet. At cosmetic concentrations (0.005%), topical effect is local and reversible. No systemic safety concern. Well-tolerated in safety studies.

Is Palmitoyl Dipeptide-5 Diaminohydroxybutyrate allowed in India?

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate is currently classified as "Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission" under Indian cosmetics regulations. The maximum permitted concentration is Not verified in source checked.

What is Palmitoyl Dipeptide-5 Diaminohydroxybutyrate used for in cosmetics?

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate functions as: Skin conditioning / Anti-ageing / Expression line reduction. It is commonly found in: Anti-wrinkle serums, expression line creams (Vialox by Pentapharm/DSM).

Can Palmitoyl Dipeptide-5 Diaminohydroxybutyrate cause an allergic reaction?

Yes. Palmitoyl Dipeptide-5 Diaminohydroxybutyrate has an allergen flag (None identified). If you have sensitive skin or known fragrance/contact allergies, patch-test products containing this ingredient before full use.

TCS Assessment
Low Concern
Data Confidence
Medium
Based on peer-reviewed safety data, regulatory status, and expert review by The Clean Sheet panel.

Regulatory Status

India (CDSCO)
Not specifically listed or restricted under Cosmetics Rules 2020; permitted by omission
EU
Permitted; listed in EU CosIng as skin conditioning agent; not restricted
US FDA
Permitted cosmetic ingredient; not listed as prohibited or restricted in 21 CFR
Korea (MFDS)
Not listed as restricted or prohibited by MFDS; permitted cosmetic ingredient
Australia (TGA)
Permitted cosmetic ingredient
Canada (NHPID)
Permitted cosmetic ingredient

EU Annex: None

Identifiers

CAS959610-30-1
ECNot assigned

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